Cucurbitacin B
作者：齐岳
发布时间：2023-09-14
09:02:00
点击数：
产品名称：Cucurbitacin B
产品描述：
| 植物来源 | 天然产物 > 葫芦科 > 葫芦属 |
| 结构类型 | 天然产物 > 萜类 |
| 产品描述 | Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells. |
| 体外活性 | Cucurbitacin B inhibits the growth of 5 GBM cell lines: U87, U118, U343, U373 and T98 g by affecting the cytoskeleton and the JNK pathway, with ED50 ranged from 5 nM to 100 nM. Cucurbitacin B also causes cell cycle arrest at the G2/M phase, decreases cell migration and induces apoptosis of GBM cells. [1] In human breast cancer cell lines, Cucurbitacin B also inhibits cell growth with ED50 varied from 30.3 nM to 418 nM, and rapidly induces cytoskeletal disruption. [2] In addition, Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects, depending on the induction of heme oxygenase-1 expression via Nrf2 activation. [3] |
| 体内活性 | In nude mice bearing MDA-MB-231 tumors, Cucurbitacin B (1 mg/kg, i.p.) inhibits tumor growth by 55 %, and causes lower serum glucose levels. [2] |
| 细胞实验 | For proliferation measurements, the cells are placed into 96 well plates, and cell growth is measured at various times by MTT assay according to the protocol.(Only for Reference) |
| 别名 | 葫芦素B, Amarine, 葫芦素 B, Cuc B, DATISCACIN |
| 分子量 | 558.7 |
| 分子式 | C32H46O8 |
| CAS No. | 6199-67-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 91 mg/mL(162.9 mM)
Chloroform, Dichloromethane, Ethyl Acetate: Soluble
Ethanol: 50 mg/mL (89.49 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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