Trimetazidine dihydrochloride
作者：齐岳
发布时间：2023-09-14
09:02:16
点击数：
产品名称：Trimetazidine dihydrochloride
产品描述：
| 产品描述 | Trimetazidine dihydrochloride can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in ischemic heart disease or angina. |
| 靶点活性 | mitochondrial long-chain 3-ketoacyl thiolase:75 nM |
| 体外活性 | Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion[3]. |
| 体内活性 | The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia[2]. |
| 细胞实验 | The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment. (Only for Reference) |
| 别名 | Kyurinett, Vastarel F, 盐酸曲美他嗪, Yoshimilon |
| 分子量 | 339.26 |
| 分子式 | C14H22N2O3·2HCl |
| CAS No. | 13171-25-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 70 mg/mL (206.33 mM),Need ultrasonic and warming
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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