Rosiglitazone hydrochloride
作者：齐岳
发布时间：2023-09-13
17:01:29
点击数：
产品名称：Rosiglitazone hydrochloride
产品描述：
| 产品描述 | Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
| 靶点活性 | PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50) |
| 体外活性 | Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2] |
| 别名 | 盐酸罗格列酮, BRL-49653 HCl, Rosiglitazone HCl |
| 分子量 | 393.89 |
| 分子式 | C18H19N3O3S·HCl |
| CAS No. | 302543-62-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 73 mg/mL (185.3 mM)
DMSO: 73 mg/mL (185.3 mM)
H2O: <1 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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