Trigonelline
作者：齐岳
发布时间：2023-09-13
17:01:45
点击数：
产品名称：Trigonelline
产品描述：
| 植物来源 | 天然产物 > 葫芦科 > 葫芦属 |
| 结构类型 | 天然产物 > 生物碱 |
| 产品描述 | Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. |
| 体外活性 | Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1]. |
| 体内活性 | Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2]. |
| 别名 | 葫芦巴碱, Trigenolline |
| 分子量 | 137.14 |
| 分子式 | C7H7NO2 |
| CAS No. | 535-83-1 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: Insoluble
DMSO: 10 mM
Ethanol: Insoluble
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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