Evixapodlin
作者：齐岳
发布时间：2023-09-13
16:37:33
点击数：
产品名称：Evixapodlin
产品描述：
| 产品描述 | Evixapodlin is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities. |
| 靶点活性 | Human PD-1/PD-L1 protein/protein interaction:0.213 nM (IC50) |
| 体外活性 | Evixapodlin exhibits an ability to increase the production of IFN-γ and Granzyme B in both CD8+ and CD4+ T cells in individuals with chronic hepatitis B (CHB). Additionally, Evixapodlin enhances the frequency of Granzyme B-positive cells among HBV-specific CD8+ and CD4+ T cells.[1] |
| 体内活性 | Evixapodlin (10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment results in over 90% occupancy of the PD-L1 target on tumor cells. Evixapodlin effectively suppresses tumor growth in a mouse colorectal tumor model (MC38) that expresses human PD-L1.[1] |
| 别名 | GS-4224, PD-1/PD-L1-IN 7 |
| 分子量 | 691.61 |
| 分子式 | C34H36Cl2N8O4 |
| CAS No. | 2374856-75-2 |
存储
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 45.0 mg/mL (65.1 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
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