Atezolizumab
作者：齐岳
发布时间：2023-09-13
16:37:32
点击数：
产品名称：Atezolizumab
产品描述：
| 产品描述 | Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1. |
| 细胞实验 | Objective: Determine the binding of [111In]PD-L1-mAb to tumor cell lines. Cells: NCI-H2444（Lung Cancer cell line）, MDAMB231（Breast Cancer cell line）,etc. Concentrations: 1 μCi/100μl. Incubation Time: 1 h. Method: Incubating 1 μCi of [111In]PD-L1-mAb with 1×106cells (in triplicate for each cell line) for 1h at 37°C. PD-L1 blocking was performed by adding a 10-fold molar equivalent excess of the non-labeled mAb. After incubation, cells were washed three times with cold PBS prior to counting on an automated gamma counter. |
| 别名 | 阿特朱单抗, 阿特珠单抗 |
| 化合物与蛋白结合的复合物 |
Crystal structure of PD-L1 complexed with atezolizumab fab at 2.9A |
| 分子量 | 145 kDa |
| CAS No. | 1380723-44-3 |
存储
store at low temperature | store at -20 ℃
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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