Autophinib
作者：齐岳
发布时间：2023-09-11
09:07:03
点击数：
产品名称：Autophinib
产品描述：
| 产品描述 | Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. |
| 靶点活性 | Autophagy:40 nM, Autophagy:90 nM |
| 体外活性 | Autophinib targets VPS34 but not other lipid kinases, mTOR and TBK1. Autophinib appears to be ATP-competitive, targets VPS34 in cell lysate and induces cellular phenotypes consistent with VPS34 inhibition. Autophinib inhibits the accumulation of autophagosomes under fed as well as starved conditions, but does not affect the number of autolysosomes. Thus it is not a late stage autophagy inhibitor but an inhibitor of autophagosome formation. |
| 细胞实验 | Cell lines: HeLa cellsConcentrations: 30 μMIncubation Time: 18 hMethod: |
| 分子量 | 346.73 |
| 分子式 | C14H11ClN6O3 |
| CAS No. | 1644443-47-9 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: <1 mg/mL
DMSO: 64 mg/mL (184.6 mM)
H2O: <1 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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