Tamoxifen
作者：齐岳
发布时间：2023-09-11
09:05:04
点击数：
产品名称：Tamoxifen
产品描述：
| 产品描述 | Tamoxifen is an antagonist of the estrogen receptor in breast tissue. |
| 体外活性 | Tamoxifen shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2]. |
| 体内活性 | The Tamoxifen-inducible gene knockout strategy has clear advantages in that expression of a gene can be ablated in adult mice at will in a tissue specific manner. To study the role of Med1 in adult heart, 7-week old TmcsMed1-/- mice are given a daily Iintraperitoneal injection of Tamoxifen at a dose of 65 mg/kg for 5 days and killed at selected intervals thereafter. qPCR analysis of RNA shows that the Med1 expression begin to decrease after 3 days of Tamoxifen injection (about 70% decrease), and by 5 days of injection, Med1 expression is almost non-detectable in the heart. Tamoxifen-inducible cardiac-specific disruption of Med1 (TmcsMed1-/-) in adult mice causes dilated cardiomyopathy[3]. |
| 别名 | ICI47699, 他莫昔芬, Z-Tamoxifen, ICI 46474, trans-Tamoxifen |
| 化合物与蛋白结合的复合物 |
TAMOXIFEN-DNA ADDUCT |
| 分子量 | 371.51 |
| 分子式 | C26H29NO |
| CAS No. | 10540-29-1 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 7.4 mg/mL (20 mM)
Ethanol: 37.2 mg/mL (100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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