ML385
作者：齐岳
发布时间：2023-09-07
09:28:12
点击数：
产品名称：ML385
产品描述：
| 产品描述 | ML385 is a new-type and selective NRF2 inhibitor. |
| 靶点活性 | Nrf2:1.9 μM |
| 体外活性 | ML385 reduce the NRF2 transcriptional activity in a dose-dependent manner with the maximum inhibitory concentration is 5 μM. ML385 interacts with NRF2 and affects the DNA binding activity of the NRF2-MAFG protein complex（IC50=1.9 μM）. |
| 体内活性 | ML385 in combination with carboplatin leads to a significant reduction in tumor cell proliferation, demonstrated by fewer Ki-67 positive cells. Tumor samples treated with ML385 show a significant reduction in NRF2 protein level and its downstream target genes. |
| 细胞实验 | cells are treated with ML385 for 36 h. An equal amount of CellTiter-Blue reagent is added to the wells and the fluorescence is measured after 30 min. The CellTiter-Blue reagent is discarded and the Caspase-Glo (100 μL) reagent is added to the cells and incubated at 37°C for an additional 60-90 min. The resulting luminescence is recorded and the caspase activity is normalized to cell number |
| 动物实验 | Mice tumor xenografts are administered intraperitoneally ML385 (30 mg/kg). |
| 分子量 | 511.6 |
| 分子式 | C29H25N3O4S |
| CAS No. | 846557-71-9 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 30 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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