Atorvastatin hemicalcium salt
作者：齐岳
发布时间：2023-09-07
09:28:11
点击数：
产品名称：Atorvastatin hemicalcium salt
产品描述：
| 产品描述 | Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication. |
| 靶点活性 | HMG-CoA reductase:8 nM |
| 体外活性 | 在statin处理过的大鼠中,Atorvastatin降低p22phox和NOX1血管mRNA的表达,同时提高主动脉过氧化氢酶的表达.在胆固醇喂养的兔子中,Atorvastatin抑制C反应蛋白的血清水平的增加. |
| 体内活性 | 在血管平滑肌细胞中, Atorvastatin（0.1 μM）能够抑制血管紧张素Ⅱ和肿瘤坏死因子-α诱导的NF-κB活化；Atorvastatin（1 μM）减少血管紧张素Ⅱ和肿瘤坏死因子-α诱导的IP-10的表达。 |
| 细胞实验 | Briefly, SV-SMC from 5 different patients are seeded into 24-well cell culture plates at a density of 1×104?cells per well in full growth medium. Cells are incubated overnight and then quiesced in serum free medium for 3 days before transfer to full growth medium (10% FCS) containing 5 different statins (simvastatin, atorvastatin, fluvastatin, lovastatin, and pravastatin)at a range of concentrations. All statins are tested on cells from each individual patient. Medium and drugs are replaced after 2 days, and viable cell numbers are determined in triplicate wells after 4 days using Trypan Blue and a hemocytometer. The increase in cell number is calculated by subtracting the starting cell number (day 0) from the final cell number (day 4). Data are then normalized to control values (no statin) to correct for differences in proliferation rates between cells from different patients. |
| 别名 | CI-981, Atorvastatin Calcium, 阿托伐他汀钙, Lipitor, Atorvastatin hemicalcium, Sortis |
| 分子量 | 1155.34 |
| 分子式 | 2(C33H34FN2O5)·Ca |
| CAS No. | 134523-03-8 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 57.8 mg/mL (100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
联系我们：
邮箱：2519696869@qq.com
QQ: 2519696869
电话：18066853083
微信：18066853083
公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
主营产品：COF、MOF单体系列：三蝶烯衍生物、金刚烷衍生物、四苯甲烷衍生物、peg、上转换、石墨烯、光电材料、点击化学、凝集素、载玻片、蛋白质交联剂、脂质体、蛋白、多肽、氨基酸、糖化学等。
