CAS:138926-19-9 Ibandronate (Sodium Monohydrate);BM-210955; RPR-102289A 化合物合成
作者:zhn
发布时间:2024-04-03
16:45:23
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产品名称:CAS:138926-19-9 Ibandronate (Sodium Monohydrate);BM-210955; RPR-102289A 化合物合成
产品描述:
Product Name:Ibandronate (Sodium Monohydrate)
Synonyms:BM-210955; RPR-102289A
CAS Number:138926-19-9
M. Wt:359.23
Target:Apoptosis
Pathway:Apoptosis
Approved Type:EMA; FDA
Biological Activity:Ibandronate Sodium Monohydrate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
Target: Others
Ibandronate (1.25-2 μM) significantly reduces endothelial cell growth, while ibandronate (2 μM) also significantly reduces capillary-like tube formation and increases apoptosis of endothelial cells. Ibandronate (< 100 μM) dose-dependently increases VEGF expression in endothelial cells [1]. Ibandronate (< 100 μM) inhibits growth of both prostate cancer cell lines (LNCaP and PC-3) in a dose dependent manner [2].
Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly reduces the risk of new morphometric vertebral fractures by 62% and 50% (p = 0.0006), respectively, in osteoporotic women after 3 years' treatment. Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly and progressively increases BMD of lumbar spine by 6.5% and 5.7%, respectively, in osteoporotic women after 3 years' treatment [3]. Ibandronate (< 125 mg/kg s.c.) results in a dose dependent increase in bone mineral density (BMD), trabecular bone volume and trabecular number, load to failure (Fmax), and yield load in long bones and vertebrae in ovariectomized rats, and increased trabecular separation in ovariectomized rats is fully prevented by all doses [4].
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