活性氧Baicalein，CAS No. 491-67-8
产品名称：活性氧Baicalein，CAS No. 491-67-8
产品描述：
产品名称：
活性氧Baicalein，CAS No. 491-67-8
产地：西安
规格：1mg 5mg 10mg
纯度：99%
用途：仅用于科研
状态：固体/粉末
储藏条件：冷藏-20℃
温馨提示：仅用于科研，不能用于人体实验！
说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息
Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse biological activities.1 It inhibits human platelet 12-lipoxygenase (12-LO) and human reticulocyte 15-LO-1 (IC50s = 0.64 and 1.6 µM, respectively) but is less potent at 15-LO-1 when the detergent Triton-X is present (IC50 = 38 µM).2 Baicalein inhibits lipid peroxidation, as assessed by production of thiobarbituric acid (TBARS; IC50 = 5 µM), and inhibits growth of Huh-7, KIM-1, and HLF human hepatocellular carcinoma cells (IC50s = 17-70 µg/ml).3,4 Baicalein increases intracellular calcium levels by increasing release from the endoplasmic reticulum and via PKC-dependent calcium channels in the plasma membrane, leading to increases in reactive oxygen species (ROS), caspase-9 and -3 activation, and apoptosis in ZR-75-1 human breast cancer cells.5 Baicalein increases levels of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in BV-2 microglia and primary microglia and decreases the level of 12- and 15-LO products.6 It also decreases symptoms of experimental autoimmune encephalomyelitis (EAE) in a mouse model of multiple sclerosis, when administered at a dose of 75 mg/kg per day.
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编辑：XAQYBIO HAO，2023年3月27日。
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