活性氧Corynoline，18797-79-0
产品名称：活性氧Corynoline，18797-79-0
产品描述：
产品名称：活性氧Corynoline，18797-79-0
产地：西安
规格：1mg 5mg 10mg
纯度：99%
用途：仅用于科研
状态：固体/粉末
储藏条件：冷藏-20℃
温馨提示：仅用于科研，不能用于人体实验！
说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息
Corynoline is an isoquinoline alkaloid that has been found in C. incisa and has diverse biological activities.1,2,3,4,5 It is an inhibitor of acetylcholinesterase (IC50 = 30.6 µM) and β-secretase 1 (BACE1; IC50s = 33.59 and 89.07 µM for FRET and immobilized enzyme reactive assays, respectively).1,2 Corynoline (1-4 µM) decreases LPS-induced NF-κB activation and further increases LPS-induced increases in Nrf2 and heme oxygenase-1 (HO-1) protein levels in human umbilical vein endothelial cells (HUVECs).3 It increases the survival rate in a mouse model of LPS- and heat-killed E. coli-induced sepsis when administered at doses of 10, 20, and 40 mg/kg.4 Corynoline selectively inhibits proliferation of B16/F10 mouse and A375 human melanoma cells (IC50s = 12.87 and 10.47 µM, respectively) over non-cancerous melanocytes (IC50 = 126.61 µM).5 It halts the cell cycle at the G2 phase and induces apoptosis and the production of reactive oxygen species (ROS) in a dose-dependent manner in the same cells. It also reduces tumor growth in a B16/F10 mouse melanoma model when administered at a dose of 20 mg/kg.
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编辑：XAQYBIO HAO，2023年3月27日。
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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