Dantrolene sodium hemiheptahydrate
作者：齐岳
发布时间：2023-09-14
09:24:28
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产品名称：Dantrolene sodium hemiheptahydrate
产品描述：
| 产品描述 | Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. Dantrolene Sodium is the sodium salt form of dantrolene, a hydantoin derivative, and direct-acting skeletal muscle relaxant. |
| 体外活性 | Dantrolene sodium can inhibit intracellular Ca2+ release from the sarcoplasmic reticulum. In the linoleic acid emulsion system, Dantrolene sodium has strong antioxidant activity. |
| 体内活性 | In contrast of the slow soleus (SOL) muscle, Dantrolene sodium (5 mg/kg) has a greater inhibitory on the twitch contraction of the fast extensor digitorum longus (EDL) muscle. |
| 别名 | Sodium dantrolene, Dantrium, Dantrolene sodium hydrate, 丹曲林钠五水合物, Dantrolene sodium salt |
| 分子量 | 399.29 |
| 分子式 | C14H9N4NaO5·3.5H2O |
| CAS No. | 24868-20-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 33 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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