BIX-01294
作者：齐岳
发布时间：2023-09-14
09:02:17
点击数：
产品名称：BIX-01294
产品描述：
| 产品描述 | BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). |
| 靶点活性 | G9a:1.9 μM |
| 体外活性 | BIX-01294 induced caspase-dependent apoptosis in human bladder cancer cells.?BIX-01294 stimulates endoplasmic reticulum stress (ER stress) and up-regulated expression of PMAIP1 through DDIT3 up-regulation.?Furthermore, down-regulation of the deubiquitinase USP9X by BIX-01294 results in downstream reduction of MCL1 expression, leading to apoptosis eventually[1]. |
| 细胞实验 | On the first day, cells were seeded in 96 well plates.?Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well.?After treatment by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1] |
| 分子量 | 490.64 |
| 分子式 | C28H38N6O2 |
| CAS No. | 935693-62-2 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 98 mg/mL (163.33 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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