Rotenone
作者：齐岳
发布时间：2023-09-14
08:56:50
点击数：
产品名称：Rotenone
产品描述：
| 植物来源 | 天然产物 > 豆科 > 鱼藤属 |
| 产品描述 | Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae). |
| 体外活性 | Mitogen Activated Protein Kinase (MAPK), Toll-like receptor, Wnt, and Ras signaling pathways are intensively involved in the effect of rotenone on the ENS[2]. Rotenone-induced cell death is reduced by MCE treatment as measured by a decline in the levels of pro-apoptotic proteins. In addition, MCE treatment significantly augments the levels of anti-apoptotic Bcl2 and blocks the release of cytochrome c, thereby alleviating the rotenone-induced dopaminergic neuronal loss, as evidenced by tyrosine hydroxylase (TH) immunostaining in the striatum[3]. |
| 体内活性 | Rotenone results in a significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate together with a significant decrease in the inhibitory amino acids, GABA, glycine and taurine are observed in the cerebellum of rat model of PD[1]. Rotenone (1.5, 2, or 2.5 mg/kg) causes a dose-dependent increase in α-synuclein in the substantia nigra. Furthermore, at 2 and 2.5 mg/kg, rotenone causes a significant decrease in the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra, and dopamine in the striatum in rats[4]. |
| 别名 | Rotocide, 鱼藤酮, Rotenon, Paraderil, Dactinol, Barbasco |
| 分子量 | 394.43 |
| 分子式 | C23H22O6 |
| CAS No. | 83-79-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 39.4 mg/mL(100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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