Crizotinib hydrochloride
作者：齐岳
发布时间：2023-09-13
17:38:34
点击数：
产品名称：Crizotinib hydrochloride
产品描述：
| 产品描述 | Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM) |
| 靶点活性 | anaplastic lymphoma kinase:20 nM , c-Met:8 nM |
| 体外活性 | Crizotinib hydrochloride(PF-2341066)potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L).?In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases.?PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells[1]. |
| 别名 | 克里唑替尼盐酸, PF-02341066 hydrochloride |
| 分子量 | 486.8 |
| 分子式 | C21H23Cl3FN5O |
| CAS No. | 1415560-69-8 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 4.9 mg/mL (10.07 mM)
H2O: 50 mg/mL (102.71 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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