Dronedarone
作者：齐岳
发布时间：2023-09-13
17:40:20
点击数：
产品名称：Dronedarone
产品描述：
| 结构类型 | 天然产物 > 生物碱 |
| 产品描述 | Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. |
| 体外活性 | Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes [1]. Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts [2]. Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold)?=?-40 mV with IC50 value of 0.4 μM, whereas at V (hold)?=?-80 mV, Dronedarone (10 μM) blocks only 20?% of the current [3]. |
| 体内活性 | Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction [4]. |
| 别名 | SR 33589, 决奈达隆 |
| 分子量 | 556.76 |
| 分子式 | C31H44N2O5S |
| CAS No. | 141626-36-0 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 27.8 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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