Oroxylin A
作者：齐岳
发布时间：2023-09-13
17:38:27
点击数：
产品名称：Oroxylin A
产品描述：
| 植物来源 | 天然产物 > 紫葳科 > 木蝴蝶属 |
| 结构类型 | 天然产物 > 类黄酮 |
| 产品描述 | 1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment. |
| 别名 | Baicalein 6-methyl ether, 千层纸素A, 6-Methoxybaicalein |
| 分子量 | 284.26 |
| 分子式 | C16H12O5 |
| CAS No. | 480-11-5 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 32 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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