Xylitol
作者：齐岳
发布时间：2023-09-13
17:30:28
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产品名称：Xylitol
产品描述：
| 植物来源 | 天然产物 > 报春花科 > 报春花属 |
| 产品描述 | Xylitol is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. |
| 体外活性 | Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression[2]. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs[1]. |
| 体内活性 | Xylitol triggers the release of insulin in dogs[3] and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug[1]. |
| 细胞实验 | In vitro tube formation assay:HUVECs (2×104 cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times. (Only for Reference) |
| 别名 | Adonitol, Adonite, Ribitol, Xylite, 木糖醇, D-Xylitol |
| 分子量 | 152.15 |
| 分子式 | C5H12O5 |
| CAS No. | 87-99-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 197.2 mM
DMSO: 197.2 mM
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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