Dioscin
作者：齐岳
发布时间：2023-09-13
17:28:04
点击数：
产品名称：Dioscin
产品描述：
| 植物来源 | 天然产物 > 薯蓣科 > 薯蓣属 |
| 结构类型 | 天然产物 > 类固醇 |
| 产品描述 | Dioscin is a saponin with antitumor activities. |
| 体外活性 | 小鼠LD50:>300 mg/kg |
| 体内活性 | Dioscin通过下调Hela细胞中caspase-8的活性,并上调caspase-9的活性诱导细胞凋亡。Dioscin抑制MDA-MB-435,H14,HL60和HeLa细胞系的生长,IC50分别为2.6,0.8,7.5以及4.5 μM。 |
| 激酶实验 | Rat liver cytosol is prepared from a separate piece of liver from rat. Assays are carried out in a total volume of 0.1 mL containing 10 mg of cytosolic protein, and components according to Rilling. All reaction components (except IPP) are mixed and kept on ice for 15 min. Reactions are initiated by the addition of [14C]IPP and incubation at 37°C. Reactions are stopped after 5 min by addition of 0.4 mL MeOH/HCl (4/1, by vol.) and the samples are incubated a further 15 min to hydrolyze the allylic pyrophosphates to petroleum ether-extractable products. Following addition of 0.5 mL water and 1 mL petroleum ether, 50% of the upper (petroleum ether-extractable) phase is taken for liquid scintillation analysis. Preliminary experiments indicated that the reaction is linear with time and protein under these conditions, and no more than 10% of the substrate is consumed. |
| 别名 | CCRIS 4123, Collettiside III, Saponin, 薯蓣皂苷, 薯蓣皂甙, 山药 |
| 分子量 | 869.04 |
| 分子式 | C45H72O16 |
| CAS No. | 19057-60-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 100 mg/mL (115.06 mM)
Ethanol: 22 mg/mL (25.31 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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