Norepinephrine bitartrate monohydrate
作者：齐岳
发布时间：2023-09-13
17:26:06
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产品名称：Norepinephrine bitartrate monohydrate
产品描述：
| 产品描述 | Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator. |
| 靶点活性 | β1-selective adrenergic receptor:5.37 μM(EC50) |
| 体外活性 | Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations' and would, through an enhancement of ‘bottom-up' information processing at the expense of irrelevant ‘top-down' expectations, favor behavioral adjustment. [1] Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. [2] Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects. [3] |
| 细胞实验 | Norepinephrine (NE)is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2]. |
| 别名 | 酒石酸去甲肾上腺素, Noradrenaline bitartrate monohydrate, Levophed, 降肾上腺素 |
| 分子量 | 337.28 |
| 分子式 | C8H11NO3·C4H6O6·H2O |
| CAS No. | 108341-18-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 31.9 mg/mL (100 mM)
DMSO: 31.9 mg/mL (100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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