Dronedarone hydrochloride
作者：齐岳
发布时间：2023-09-13
17:21:45
点击数：
产品名称：Dronedarone hydrochloride
产品描述：
| 产品描述 | Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation. |
| 体外活性 | Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. [1] Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. [2] Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold)?=?-40 mV with IC50 value of 0.4 μM, whereas at V (hold)?=?-80 mV, Dronedarone (10 μM) blocks only 20?% of the current. [3] |
| 体内活性 | Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction. [4] |
| 别名 | SR33589, 决奈达隆盐酸盐, 盐酸决奈达隆, Dronedarone HCl |
| 分子量 | 593.22 |
| 分子式 | C31H44N2O5S·HCl |
| CAS No. | 141625-93-6 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 74 mg/mL (124.7 mM)
Ethanol: 38 mg/mL (64.1 mM)
H2O: <1 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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