STF-31
作者：齐岳
发布时间：2023-09-13
17:12:05
点击数：
产品名称：STF-31
产品描述：
| 产品描述 | STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM. |
| 靶点活性 | GLUT1:1 μM. |
| 体外活性 | STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. [1] In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. [2] STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. [3] |
| 体内活性 | In mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth. [1] |
| 分子量 | 423.53 |
| 分子式 | C23H25N3O3S |
| CAS No. | 724741-75-7 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 25 mg/mL (59.03 mM)
DMSO: 42.4 mg/mL(100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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