Tomatidine
作者：齐岳
发布时间：2023-09-13
17:12:01
点击数：
产品名称：Tomatidine
产品描述：
| 植物来源 | 天然产物 > 茄科 > 番茄属 |
| 结构类型 | 天然产物 > 生物碱 |
| 产品描述 | Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans. |
| 体外活性 | Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. METHODS AND RESULTS: We have recently demonstrated that Tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, Tomatidine has shown antibiotic activity against small-colony variants of S. aureus. CONCLUSIONS: We herein report the first study of the structure-activity relationship of Tomatidine against S. aureus. |
| 分子量 | 415.65 |
| 分子式 | C27H45NO2 |
| CAS No. | 77-59-8 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
0.1 M HCL: < 1 mg/mL (insoluble)
DMSO: 2.86 mg/mL (6.88 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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