6,4'-Dihydroxy-7-methoxyflavanone
作者：齐岳
发布时间：2023-09-13
17:11:36
点击数：
产品名称：6,4'-Dihydroxy-7-methoxyflavanone
产品描述：
| 产品描述 | 6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases. |
| 体外活性 | 6,4'-Dihydroxy-7-methoxyflavanone showed inhibition of osteoclasts differentiation and function. 6,4'-Dihydroxy-7-methoxyflavanone increased cellular resistance to oxidative injury caused by glutamate-induced cytotoxicity in HT22 cells, via JUN N-terminal kinase (JNK) pathway dependent (HO)-1 expression. 6,4'-Dihydroxy-7-methoxyflavanone suppressed the lipopolysaccharide (LPS)-induced expression of pro-inflammatory enzymes and inflammatory mediators in BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone suppressed production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression. CONCLUSIONS: This study indicates that 6,4'-Dihydroxy-7-methoxyflavanone effectively modulates the regulation of anti-oxidative and anti-inflammatory action, via up-regulation of HO-1 in HT22 cells and BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone possesses therapeutic potentials against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation[1]. |
| 别名 | 檀木, 6,4'-二羟基-7-甲氧基二氢黄酮 |
| 分子量 | 286.28 |
| 分子式 | C16H14O5 |
| CAS No. | 189689-32-5 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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