Trifluoperazine dihydrochloride
作者：齐岳
发布时间：2023-09-13
17:05:53
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产品名称：Trifluoperazine dihydrochloride
产品描述：
| 产品描述 | Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. |
| 靶点活性 | Dopamine D2 receptor:1.1 nM |
| 体外活性 | Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5] |
| 体内活性 | Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6] |
| 别名 | Urinox, 盐酸三氟拉嗪, SKF5019, Trifluoperazine 2HCl |
| 分子量 | 480.43 |
| 分子式 | C21H26Cl2F3N3S |
| CAS No. | 440-17-5 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 88 mg/mL (183.2 mM)
DMSO: 82 mg/mL (170.7 mM)
Ethanol: 89 mg/mL (185.3 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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