4E2RCat
作者：齐岳
发布时间：2023-09-13
17:04:05
点击数：
产品名称：4E2RCat
产品描述：
| 产品描述 | 4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression and the production of infectious virus. |
| 靶点活性 | eIF4E-eIF4G:13.5 μM |
| 体外活性 | 4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner[1]. |
| 体内活性 | 4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1]. |
| 分子量 | 455.93 |
| 分子式 | C22H14ClNO4S2 |
| CAS No. | 432499-63-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 15.5 mg/mL (34.00 mM),Need ultrasonic and warming
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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