Pifithrin-β hydrobromide
作者：齐岳
发布时间：2023-09-13
17:01:30
点击数：
产品名称：Pifithrin-β hydrobromide
产品描述：
| 产品描述 | Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM). |
| 靶点活性 | p53:23 μM(EC50) |
| 体外活性 | PFTα molecule could not take a planar conformation required for AhR activation whereas PFTβ showed a conformation similar to those of the prototypical AhR ligand β-naphthoflavone. In both cell lines, PFTα and PFTβ provoked different responses related with AhR activation. However, when cyclization of PFTα to PFTβ was hampered by acetylation of the exocyclic nitrogen, all these responses were not observed. These results lead to the conclusion that the activation of the AhR is probably caused by PFTβ instead of PFTα. |
| 别名 | Pifithrin-β, Cyclic PFT-α, PFT-β, Cyclic Pifithrin-α hydrobromide, PFT β (hydrobromide) |
| 分子量 | 349.29 |
| 分子式 | C16H17BrN2S |
| CAS No. | 511296-88-1 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 26 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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