AZA1
作者：齐岳
发布时间：2023-09-13
16:39:26
点击数：
产品名称：AZA1
产品描述：
| 产品描述 | AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion. |
| 体外活性 | AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) impedes the proliferation of human 22Rv1 prostate cancer cells.[1]AZA1 (2-10 μM; 24 hours) diminishes phosphorylation of PAK1, AKT, and BAD in EGF-stimulated 22Rv1 prostate cancer cells.[1]AZA1 (10 μM; 24 hours) obstructs Rac1 and Cdc42-dependent cell cycle progression in 22Rv1 prostate cancer cells. AZA1 inhibits Rac1 and Cdc42-dependent migration of 22Rv1, DU 145, and PC-3 prostate cancer cells.[1]AZA1 influences cell motility and actin reorganization in prostate cancer cells by suppressing Rac1 and Cdc42 function through PAK1/2 phosphorylation.[1] |
| 体内活性 | AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice (5 week-old athymic nu/nu (nude)) and improving survival. The suppressive effect of AZA1 on tumor growth was significant.[1] |
| 别名 | Rac1/Cdc42-IN-1 |
| 分子量 | 368.43 |
| 分子式 | C22H20N6 |
| CAS No. | 1071098-42-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 45.0 mg/mL (122.1 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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