Y-39983 hydrochloride
作者：齐岳
发布时间：2023-09-13
16:37:42
点击数：
产品名称：Y-39983 hydrochloride
产品描述：
| 产品描述 | Y-39983 hydrochloride is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor. |
| 体内活性 | In rabbits, topical administration of Y-39983 significantly increased conventional outflow by 65.5%, followed by significant, dose-dependent reduction in IOP. Maximum IOP reduction was 13.2 ± 0.6 mm Hg (mean ± SE) at 0.1% Y-39983 in rabbits. In monkeys, at 3 hours after topical administration of 0.05% Y-39983, maximum reduction of IOP was 2.5 ± 0.8 mm Hg. No serious side effects were observed in ocular tissues except sporadic punctate subconjunctival hemorrhage during long-term topical administration of Y-39983 four times a day (at 2-hour intervals) in rabbits or monkeys. However, punctate subconjunctival hemorrhage was not observed with administration twice daily (at a 6-hour interval) or three times a day (at 5-hour intervals)[1]. |
| 别名 | RKI-983, SNJ-1656, Y-33075 HCl, 盐酸Y-39983, Y-39983 HCl |
| 分子量 | 316.79 |
| 分子式 | C16H17ClN4O |
| CAS No. | 471843-75-1 |
存储
store at low temperture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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