BMS-1166
作者：齐岳
发布时间：2023-09-13
16:37:16
点击数：
产品名称：BMS-1166
产品描述：
| 产品描述 | BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor. |
| 靶点活性 | PD-1/PD-L1:1.4 nM |
| 体外活性 | BMS-1166 alleviate the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Moreover, the compounds were effective in attenuating the inhibitory effect of the cell surface-associated PD-L1. |
| 激酶实验 | Purified proteins in 10 mM Tris (pH 8.0) containing 20 mM NaCl, were concentrated to 5 mg/ml, mixed with the inhibitor in 1:3 molar ratio (protein:compound) and clarified by centrifugation at 15 000 × g for 10 min. Supernatant was used for screening using a sitting-drop vapor diffusion method. Diffraction-quality crystals were obtained at room temperature from 0.1 M Tris pH 8.5 containing 0.2 M magnesium chloride and 30% (w/v) PEG 4000 for the hPD-L1/BMS-1001 complex and from 0.01 M Tris pH 8.4 containing 0.28 M sodium chloride and 27% (w/v) PEG 4000 for hPD-L1/BMS-1166 complex. |
| 分子量 | 641.11 |
| 分子式 | C36H33ClN2O7? |
| CAS No. | 1818314-88-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 125 mg/mL (194.97 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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