Isoniazid
作者：齐岳
发布时间：2023-09-13
09:11:29
点击数：
产品名称：Isoniazid
产品描述：
| 产品描述 | Isoniazid is an antibacterial agent used primarily as a tuberculostatic. |
| 体外活性 | Isoniazid is a prodrug that requires activation by the mycobacterial catalase-peroxidase enzyme (KatG) to an active form that then exerts a lethal effect on an intracellular target or targets. [1] Isoniazid upregulates the expression of an operon containing five FAS II components, including kasA and acpM. Isoniazid results in the accumulation of ACP-bound lipid precursors to mycolic acids that are 26 carbons long and fully saturated. [2] Isoniazid enters the mycobacterial cell by passive diffusion. Isoniazid itself is not toxic to the bacterial cell, but acts as a prodrug and is activated by the mycobacterial enzyme KatG, a multifunctional catalase-peroxidase that has other activities, including peroxynitritase and NADH oxidase. Isoniazid inhibits cell wall lipid synthesis, coupled with the findings that inhibitory INH adducts of NAD+/NADP+ are formed from the isonicotinoyl radical, leading the field away from this area. [3] Isoniazid induces a concentration-dependent (0-40 mM) cytotoxic effect in day-1 treated HepG2 cells and not significantly affected by decreases in intracellular GSH concentrations. [4] |
| 体内活性 | Isoniazid increases CYP2E1 protein, and the 6-hydroxychlorzoxazone formation rate is increased by 2.7 and 2.2-fold in liver and kidney, respectively. Isoniazid decreases liver and kidney 20-HETE content to 34% and 15.6% of control, respectively, without significantly altering tissue 19-HETE concentration. [5] |
| 别名 | INH, 异烟肼, Isonicotinic hydrazide, Isonicotinic acid hydrazide |
| 分子量 | 137.14 |
| 分子式 | C6H7N3O |
| CAS No. | 54-85-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 26 mg/mL (189.6 mM)
H2O: 25 mg/mL (182.3 mM)
Ethanol: 26 mg/mL (189.6 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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