Motixafortide TFA(664334-36-5,Free)
作者：齐岳
发布时间：2023-09-12
09:12:42
点击数：
产品名称：Motixafortide TFA(664334-36-5,Free)
产品描述：
| 产品描述 | Motixafortide is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression. |
| 靶点活性 | CXCR4:～1 nM |
| 体外活性 | Treatment with BL-8040 induces the robust mobilization of AML blasts from the BM. In addition, AML cells exposed to BL-8040 undergoes differentiation. BL-8040 induces the apoptosis of AML cells in vitro, which is mediated by the up-regulation of miR-15a/miR-16-1, resulting in down-regulation of the target genes BCL-2, MCL-1 and cyclin-D1. Overexpression of miR-15a/miR-16-1 directly induces leukemic cell death. BL-8040-induced apoptosis is also mediated by the inhibition of survival signals via the AKT/ERK pathways. |
| 体内活性 | BL-8040 also synergizes with FLT3 inhibitors to induce AML cell death. Importantly, this combined treatment prolongs the survival of tumor-bearing mice and reduces minimal residual disease in vivo. |
| 别名 | TF 14016 TFA, BKT140 TFA, T140 TFA, BL-8040 TFA |
| 分子量 | 2273.54 |
| 分子式 | C99H145F4N33O21S2 |
| CAS No. | T14665L |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 100 mg/mL (46.31 mM),need ultrasonic
DMSO: 100 mg/mL (46.31 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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