Nicotinamide N-oxide
作者：齐岳
发布时间：2023-09-12
09:09:16
点击数：
产品名称：Nicotinamide N-oxide
产品描述：
| 植物来源 | 天然产物 > 茄科 > 烟草属 |
| 产品描述 | Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase. |
| 体外活性 | Nicotinamide is one of the forms of vitamin B3. It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide[1]. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC50=10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC50=110 nM) and potent inhibitor of neutrophil chemotaxis (IC50=170 nM)[2]. |
| 别名 | Nicotinamide-N-oxide, 1-oxynicotinamide, Nicotinamide 1-oxide, N-氧代烟酰胺, 烟酰胺-N-氧化物 |
| 分子量 | 138.12 |
| 分子式 | C6H6N2O2 |
| CAS No. | 1986-81-8 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 8 mg/mL(57.9 mM)
H2O: Limited solubility
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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