Adenosine 5′-diphosphoribose sodium
产品名称:Adenosine 5′-diphosphoribose sodium
产品描述:
产品描述 | Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. It also can enhance autophagy. |
体外活性 | In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of PARP-1 produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress [1]. |
别名 | ADP ribose sodium, 二磷酸腺苷核糖, Adenosine 5'-diphosphoribose sodium |
分子量 | 582.307 |
分子式 | C15H23N5NaO14P2 |
CAS No. | 68414-18-6 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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