BRD5631
作者：齐岳
发布时间：2023-09-12
09:05:37
点击数：
产品名称：BRD5631
产品描述：
| 产品描述 | BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease. [1]. |
| 体外活性 | BRD5631 (10 μM, 48 hours) results in increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay [1]. BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner [1]. Cell Viability Assay [1] Cell Line: HeLa cells. Concentration: 10 μM. Incubation Time: 48 hours. Result: Led to increased levels of LC3-II. |
| 分子量 | 501.62 |
| 分子式 | C30H35N3O4 |
| CAS No. | 2446154-91-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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