Tempol
作者：齐岳
发布时间：2023-09-12
09:04:27
点击数：
产品名称：Tempol
产品描述：
| 产品描述 | Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects. |
| 体外活性 | Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2] |
| 体内活性 | Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6] |
| 细胞实验 | The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).(Only for Reference) |
| 别名 | TMPN, 阻聚剂701, Tanol, 4-Hydroxy-TEMPO |
| 分子量 | 172.24 |
| 分子式 | C9H18NO2 |
| CAS No. | 2226-96-2 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 17.2 mg/mL (100 mM)
DMSO: 17.2 mg/mL (100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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