Rottlerin
作者：齐岳
发布时间：2023-09-12
08:53:05
点击数：
产品名称：Rottlerin
产品描述：
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation. |
| 靶点活性 | PKCγ:40 μM(baculovirus-infected Sf9 insect cells), PKA:78 μM, PKCδ:3 μM(Porcine spleen), PKCζ:100 μM(baculovirus-infected Sf9 insect cells), PKCη:82 μM(baculovirus-infected Sf9 insect cells), PKCε:100 μM(baculovirus-infected Sf9 insect cells), CKII:30 μM(holoenzyme expressed in E.coli), PKCβ:42 μM(baculovirus-infected Sf9 insect cells), PKCα:30 μM(baculovirus-infected Sf9 insect cells) |
| 体外活性 | Rottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2]. |
| 体内活性 | Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3]. |
| 别名 | NSC 94525, Mallotoxin, 粗糠柴苦素, NSC 56346 |
| 分子量 | 516.54 |
| 分子式 | C30H28O8 |
| CAS No. | 82-08-6 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 2 mg/mL (3.87 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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