XRK3F2
作者：齐岳
发布时间：2023-09-12
08:55:08
点击数：
产品名称：XRK3F2
产品描述：
| 产品描述 | XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. |
| 体外活性 | XRK3F2 inhibits p62-ZZ domain signaling and rescues Myeloma-induced Gfi1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression. XRK3F2 prevents MM-induced upregulation of Gfi1 and repression of the Runx2 gene when present in MM-preOB co-cultures. p62-ZZ-domain blocking by XRK3F2 prevents MM conditioned media and TNF plus IL7-mediated Gfi1 mRNA upregulation and the concomitant Runx2 repression. XRK3F2 decreased MM-induced GFI1 occupancy at the Runx2-P1 promoter and prevented recruitment of HDAC1, thus preserving the transcriptionally permissive chromatin mark H3K9ac on Runx2 and allowing osteogenic differentiation[1]. |
| 分子量 | 435.89 |
| 分子式 | C23H24ClF2NO3 |
| CAS No. | 2375193-43-2 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 135.0 mg/mL (309.7 mM),Need ultrasonic
H2O: 0.8 mg/mL (1.9 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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