Vps34-IN-1
作者：齐岳
发布时间：2023-09-12
08:53:19
点击数：
产品名称：Vps34-IN-1
产品描述：
| 产品描述 | Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. |
| 靶点活性 | Vps34:25 nM |
| 体外活性 | Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain[1]. |
| 别名 | VPS34-IN1 |
| 分子量 | 425.91 |
| 分子式 | C21H24ClN7O |
| CAS No. | 1383716-33-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: <1 mg/mL
Ethanol: 79 mg/mL (185.5 mM)
DMSO: 79 mg/mL (185.5 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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