Tenovin-6
作者：齐岳
发布时间：2023-09-11
09:29:21
点击数：
产品名称：Tenovin-6
产品描述：
| 产品描述 | Tenovin-6 is a p53 transcriptional activity agonist. |
| 靶点活性 | SIRT3:67 μM, SIRT1:21 μM, SIRT2:10 μM |
| 体内活性 | Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1]. |
| 激酶实验 | Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr. |
| 细胞实验 | The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve. |
| 别名 | Tenovin 6 |
| 分子量 | 454.63 |
| 分子式 | C25H34N4O2S |
| CAS No. | 1011557-82-6 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: <1 mg/mL
DMSO: 91 mg/mL (200.2 mM)
H2O: 90 mg/mL (198 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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