Glaucocalyxin B
作者：齐岳
发布时间：2023-09-11
09:24:19
点击数：
产品名称：Glaucocalyxin B
产品描述：
| 植物来源 | 天然产物 > 唇形科 > 香茶菜属 |
| 结构类型 | 天然产物 > 萜类 |
| 产品描述 | Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM). |
| 靶点活性 | HL-60 cell Growth:5.86 μM (IC50) |
| 体外活性 | Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells (IC50s: 6.15 and 5.86 μM at 24 h). Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells[1]. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis and autophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose-dependent manner. GlnB increases the apoptotic cell population and enhanced poly (ADP ribose) polymerase 1 cleavage [2]. |
| 细胞实验 | The microglia cell viability is assessed by MTT assay. Cells are seeded in 96-well plates at the density of 5 × 10^4 cells/well. The cell culture supernatant is discarded after treatment with various agents, and then 30 μL of MTT (0.5 mg/mL) solution is added into each well. After incubation for 4 h at 37 °C, 100 μL of DMSO is added into each well to dissolve the formazan dye, and then the absorbance of solubilized formazan is measured by microplate reader [3]. |
| 别名 | 蓝萼乙素 B, 蓝萼乙素 |
| 分子量 | 374.47 |
| 分子式 | C22H30O5 |
| CAS No. | 80508-81-2 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: Soluble
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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