Brevilin A
作者：齐岳
发布时间：2023-09-08
09:07:27
点击数：
产品名称：Brevilin A
产品描述：
| 植物来源 | 天然产物 > 菊科 > 石胡荽属 |
| 结构类型 | 天然产物 > 萜类 |
| 产品描述 | Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour |
| 靶点活性 | STAT3 signaling:10.6 µM (IC50) |
| 体外活性 | In vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima.?The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).? |
| 分子量 | 346.41 |
| 分子式 | C20H26O5 |
| CAS No. | 16503-32-5 |
存储
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 100 mg/mL (288.67 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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