Imidazole ketone erastin
作者：齐岳
发布时间：2023-09-07
09:28:09
点击数：
产品名称：Imidazole ketone erastin
产品描述：
| 产品描述 | Imidazole ketone erastin (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter. |
| 体外活性 | Human astrocytoma cells (CCF-STTG1) were used, which contain the system xc?.17 Following a 2 h incubation period, glutamate released into the medium was detected fluorometrically using glutamate oxidase, horseradish peroxidase, and Amplex UltraRed. Dramatic improvement of the half-maximal inhibitory constants (IC50) for system xc? inhibition was observed for IKE (IC50: 30 nM), compared to erastin and PE [1]. |
| 体内活性 | In a diffuse large B cell lymphoma (DLBCL) xenograft model, IKE exerted an antitumor effect by inhibiting system xc-, leading to glutathione depletion, lipid peroxidation, and the induction of ferroptosis biomarkers [2]. |
| 别名 | IKE |
| 分子量 | 655.14 |
| 分子式 | C35H35ClN6O5 |
| CAS No. | 1801530-11-9 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 100 mg/mL (152.64 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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