Sappanchalcone
作者：齐岳
发布时间：2023-09-07
09:26:09
点击数：
产品名称：Sappanchalcone
产品描述：
| 植物来源 | 天然产物 > 豆科 > 云实属 |
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor. |
| 体外活性 | The influence of the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably-transfected with NF-κB, STAT1, or STAT3 responsive luciferase reporter plasmid. The inhibitory effect on the cell cycle was determined by flow cytometric analysis. The anti-tumor activities were assessed in vitro and in vivo. The EtOAc extract of Lignum Sappan had inhibitory activities on growth-related signaling and cell mitosis. Three major active compounds were Sappanchalcone, brazilin, and butein. Sappanchalcone blocked cell cycle progression in the G2/M phase, brazilin inhibited TNFα±/NF-κB signaling, while butein inhibited IL-6/STAT3 signaling, as well as TNFα±/NF-κB signaling. The three compounds all demonstrated cytotoxic activities against human tumor cells in vitro. In a S180 tumor cell-bearing mice model, the anti-tumor efficacy of the EtOAc extract was better than the individual compounds acting alone[1] |
| 别名 | 苏木查耳酮 |
| 分子量 | 286.28 |
| 分子式 | C16H14O5 |
| CAS No. | 94344-54-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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