norbergenin
作者：齐岳
发布时间：2023-09-07
09:22:15
点击数：
产品名称：norbergenin
产品描述：
| 植物来源 | 天然产物 > 其他（植物来源） > 其他 |
| 产品描述 | Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi. |
| 体内活性 | Study showed that the oral administration of Bergenin (1) and Bergenin (1) at doses of 5, 10, 20, 40 and 80 mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2,?IFN-gamma and TNF-alpha) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice.?This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity.?At similar dose levels, the effect of 2 was found to be more than that of 1.?The oral LD(0) for 1 and 2 was more than 2000 mg/kg body weight of the mice. |
| 分子量 | 314.25 |
| 分子式 | C13H14O9 |
| CAS No. | 79595-97-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 30 mg/mL (95.47 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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