Ilexgenin A
作者：齐岳
发布时间：2023-09-07
09:22:14
点击数：
产品名称：Ilexgenin A
产品描述：
| 植物来源 | 天然产物 > 冬青科 > 冬青属 |
| 结构类型 | 天然产物 > 萜类 |
| 产品描述 | Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr |
| 体外活性 | Ilexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr.treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs.?The underlying mechanism of IA was investigated on oxidized low-density lipoprotein (Ox-LDL)-induced THP-1 cells.?Pre-treatment with IA decreased active inflammation cytokines involving interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α) expression in a concentration-dependent manner.IA inhibited the phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), IKKα phosphorylation and NF-κB activity induced by Ox-LDL.?Overall, these findings define IA as a novel drug candidate for anti-atherosclerotic therapy[2]. |
| 分子量 | 502.69 |
| 分子式 | C30H46O6 |
| CAS No. | 108524-94-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 11 mg/mL (21.88 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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