Macluraxanthone
作者：齐岳
发布时间：2023-09-07
09:22:11
点击数：
产品名称：Macluraxanthone
产品描述：
| 结构类型 | 天然产物 > 类黄酮 |
| 产品描述 | Macluraxanthone has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the polarization of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86 while decreasing their expression of CD14, CD11b and CD80. Macluraxanthone significantly reduced the production of TNF-α and IL-10 cytokines in the presence of the pro-inflammatory stimulant lipopolysaccharide. |
| 体外活性 | Macluraxanthone (3 and 10 μM), at non-toxic effective doses,significantly inhibited B16F10 cell invasion, to a greater extent than 10 μM doxorubicin, while reducing migration of cancer cells without cellular cytotoxicity. Our findings indicate for the first time that active macluraxanthone isolated from Maclura amboinensis Bl. roots affect multistep of cancer metastasis processes including proliferation, adhesion, invasion and migration, possibly through induction of apoptosis of highly metastatic B16F10 melanoma cells.[1] |
| 体内活性 | We investigated the in vivo therapeutic effects of the two xanthones in a xenograft murine model of human CLL, developed by engrafting CD5-transfected chronic leukemia B cells into SCID mice. Treatment of the animals with five daily injections of macluraxanthone (5 mg/kg) resulted in a significant prolongation of their survival as compared to control animals injected with the solvent alone (p = 0.0006 and p = 0.0141, respectively). These data show for the first time the in vivo antileukemic activities of two plant-derived xanthones.[2] |
| 别名 | 3-Hydroxyblancoxanthone |
| 分子量 | 394.42 |
| 分子式 | C23H22O6 |
| CAS No. | 5848-14-6 |
存储
store at low temperture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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