Diclofenac Potassium
作者：齐岳
发布时间：2023-09-05
08:53:53
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产品名称：Diclofenac Potassium
产品描述：
| 产品描述 | Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
| 靶点活性 | Ovine COX-2:0.84 nM (IC50), Human COX-1:4 nM (IC50, in CHO cells), Human COX-2:1.3 nM (IC50, in CHO cells), Ovine COX-1:5.1 nM (IC50) |
| 体外活性 | The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. |
| 别名 | 双氯芬酸钾, Voltfast, Cataflam, CGP-45840B |
| 分子量 | 334.24 |
| 分子式 | C14H10Cl2KNO2 |
| CAS No. | 15307-81-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 10 mg/mL (29.91 mM)
Ethanol: <1 mg/mL
DMSO: 64 mg/mL (191.5 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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